Causes of baldness, gray hair identified

Perhaps a study of a rare genetic disease a cure for gray hair and hair loss, after researchers inadvertently discovered mechanisms that give conditions.

Co-author of the study, Dr. Lu Le, Comprehensive Cancer Center Harold C. Simmons from the University of Texas in Dallas, and colleagues undertook to investigate a disorder called neurofibromatosis type 1 (NF1), a genetic disease that nerve glands grow

The purpose of the study was to discover the mechanisms of tumor growth in NF1. Instead, the researchers identified the processes responsible for hair loss and age, a finding that could lead to new treatments for the ailments.

Researchers recently reported their findings in the genes of the newspaper and development.

Women after American hair loss in 35 years about two-thirds of people in the US will have a degree of hair loss, and all those who have the condition in the US are 40 percent.

As for gray hair, a 2012 study found that about 6-23 percent of adults worldwide expect to have at least 50 percent coverage of gray hair at the age of 50 years.

While hair loss and aging are considered by many to be a normal part of aging, for some, the conditions can be very painful. Dr. And his colleagues believe that their discovery could pave the way for new treatments against hair loss and gray hair.

The results could lead to topical treatments

The team found that studies had already identified that hair follicles contains stem cells that play a role in the production of hair, and a protein called the stem factor (SCF) involved in the pigmentation of the hair.

In her study, Dr. Le and the team that called the stem cells, once they move on the basis of hair follicles, called a protein called Krox20 – known for their role in the development of neurons – is in the cells that form the hair cells.

The researchers found that when Krox20 activated, hair precursor cells produce CFS that revealed that is critical for hair pigmentation.

In mice with skin cells that have Krox20 and CFS, the researchers found that the skin cells communicate with melanocyte cells to form pigmented hair. The melanocytes produce melanin, the pigment that gives color to the skin, hair and eyes.

When researchers removed CFS in mice, the researchers found that rodents have grown gray hairs, and the hair turned white with age. In the production of cells Krox20 was deleted, the mice did not grow hair.

The researchers say their findings suggest that abnormalities in CFS Krox20 and play an important role in hair loss and aging, although human studies are required to confirm their results.

“While this project was launched to understand how certain types of tumors have formed, we finally learn why hair becomes gray and discover the identity of the cell that leads directly to the hair.
With this knowledge, we want to create a topical link in the future or ensure the gene necessary to provide the hair follicles to solve the aesthetic problems in order to deliver. ”
(Dr. Lu Le)


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